P2X receptors are widely expressed in the liver, including P2X1~P2X7 subtypes, P2X1R, P2X2R, P2X3R, P2X4R, and P2X7R are expressed in hepatocytes and Non-parenchymal cells, including hepatocytes, Kupffer cells, bile duct cells, hepatic stellate cell, hepatic fibroblasts, hepatocellular adenocarcinoma, and hepatocellular carcinoma (Fausther et al., 2012). This evidence concerns the gene P2RX7 and hepatocellular carcinoma.