P2RX7 and Sepsis: The severity of sepsis can be linked to excessive inflammatory responses resulting in hepatic injury, P2X7R activation by e-ATP exacerbates inflammation by augmenting cytokine production, while CD39 (ENTPD1) scavenges e-ATP to generate adenosine, thereby limiting P2X7 activation and resulting in A2A receptor stimulation (Savio et al., 2017).