Künzli and his team propose the role of purinergic signal transduction in the chronic pancreatitis; their study confirmed a significant increase in transcripts of exonucleases and P2R (P2X7R, P2Y2R, and P2Y6R) in chronic pancreatitis and is associated with chronic inflammation and neoplasia of the pancreas (Künzli et al., 2007). Here, P2RY2 is linked to chronic pancreatitis.