P2RX7 and pancreatic ductal adenocarcinoma: In 2015, Giannuzzo and his team confirmed that P2X7 is overexpressed in human pancreatic ductal adenocarcinoma cell line (PDAC), and regulated the survival, migration, and invasion of pancreatic ductal adenocarcinoma cells, in which P2X7R had different effects on PDAC cell survival.