NLRP3 and Hepatic steatosis: Li and his colleagues also found that Pleurotus citrinopileatus aqueous extract inhibits inflammation by regulating SIRT1-AMPK sum to improve alcoholic hepatic steatosis and inhibit the activation of P2X7R-NLRP3 inflammatory bodies, thus achieve the purpose of treating alcoholic fatty liver (Li et al., 2018a).