Therefore, it is concluded that the activation of NLRP3 inflammatory bodies mediated by P2X7R may be involved in the production of IL-1β in hepatic stellate cells, and blocking the axis of P2X7R-NLRP3 inflammatory bodies may be a potential target for the treatment of hepatic fibrosis (Jiang et al., 2017). This evidence concerns the gene IL1B and Hepatic fibrosis.