CASP1 and Hepatic steatosis: In addition, it was found that gentiopicroside ameliorates have a protective effect on alcoholic fatty liver induced by acetaldehyde in acute and chronic alcoholic fatty liver model, and could inhibit the activation of NLRP3 inflammasome thereby inhibiting the production of IL-1β and Caspase-1 by inhibiting the P2X7R (Li et al., 2018b).