In addition, there are several reports about the role of BK channel in hypoxic-modulated cardiovascular diseases, like pulmonary artery hypertension derived from COPD, chronic inhalation of CO, or OSA (Bonnet et al., 2003; Dubuis et al., 2005; Peinado et al., 2008; Navarro-Antolín et al., 2009; Roth et al., 2009; Ahn et al., 2012; Barnes et al., 2018; Liu et al., 2018b; Li et al., 2019). The gene discussed is KCNMA1; the disease is obstructive sleep apnea syndrome.