As leptin deficiency/resistance has been associated with immune dysregulation and altered cytokine production, impairments of leptin signaling may hinder the cooperative interplay of the immunologic, metabolic, and neuro-endocrinologic processes (White et al., 2013; Guglielmi et al., 2021), potentially playing a role in driving the COVID-19 cytokine storm. The gene discussed is LEP; the disease is COVID-19.