Secondly, stronger LRTC in the range 11–18 Hz of the STXBP1 syndrome patients is in line with increased LRTC observed in intracranially recorded oscillations around seizure loci in patients with epilepsy (Parish et al., 2004; Stead et al., 2005; Monto et al., 2007). Here, STXBP1 is linked to Down syndrome.