Piezo1 is highly expressed in VSMCs of murine small-diameter arteries (e.g., cutaneous caudal artery and cerebral arteries) and, while it is not involved in the myogenic response, VSMC-specific knockout attenuates hypertension-induced inward remodeling and VSMC hypertrophy in the cutaneous caudal resistance artery. This evidence concerns the gene PIEZO1 and Hypertension.