In order to correlate the above-mentioned preclinical efficacy of these two second-generation antidepressants with an antioxidant activity of these drugs, we examined the mRNA levels of iNOS and Nox2, two pro-oxidant enzymes synergistically able to promote neuronal death through the production of ROS and RNS (Beckman and Crow, 1993), in the hippocampus of Aβ-injected mice, a brain area strongly affected in both depression and AD (Villa et al., 2016; Setti et al., 2017). This evidence concerns the gene NOS2 and depressive disorder.