IGFBP2 and chronic kidney disease: In studies related to chronic kidney disease, circulating IGFBP-2 increased in CKD patients with different conditions, including experimental uremia, CKD caused by heart failure, and children with CKD (Powell et al., 1996; Tönshoff et al., 1997; Mahesh and Kaskel, 2008; Narayanan et al., 2012; Mirna et al., 2020; Ravassa et al., 2020).