The heparin domain of IGFBP-5 mediate the migration of the mesangial cells by combining cdc42 in the high glucose environment (Abrass et al., 1997; Berfield et al., 2000), and IGFBP-5 increases in the glomerular hypertrophy of early diabetes (Schaeffer et al., 2010). The gene discussed is IGFBP5; the disease is diabetes mellitus.