Except these, a study including a large population based of 4,028 men and women aged 20–81 years with adjusting for age, waist circumference and type 2 diabetes mellitus showed that IGFBP-3 increases in the blood circulation of in CKD and is negatively correlated with eGFR (Dittmann et al., 2012), However, whether IGFBP-3 is involved in the pathogenesis of CKD or merely serves as a biomarker to indicate the presence of CKD remains to be further studied. This evidence concerns the gene IGFBP3 and diabetes mellitus.