The abundance of IGFBP-6 in plasma of adults and children with CKD or ERSD were all significantly up-regulated (Jarkovská et al., 2005; Christensson et al., 2018), Consistent with these, the monitoring of plasma IGFBP-6 before and after kidney transplantation and at the time of rejection showed that IGFBP-6 indicate the status of renal function in patients with chronic renal insufficiency (Fukuda et al., 1998), level of IGFBP-6 increases significantly by 8–25 times with the decrease of renal function (Jehle et al., 2000). Here, IGFBP6 is linked to chronic kidney disease.