What’s more, clinical studies have also tracked the renal function level and plasma IGFBP-2 concentration of more than 400 patients with diabetic nephropathy over an 8-year period, suggesting that IGFBP-2 is a biomarker to predict longitudinal deterioration of renal function in patients with type 2 diabetes (Narayanan et al., 2012). The gene discussed is IGFBP2; the disease is diabetic kidney disease.