TIMP2 and acute kidney injury: A year later, the Topaz study prospectively validated the urinary [TIMP-2]•[IGFBP-7] test’s ability (at the 0.3 cutoff level) to identify critically ill patients at high risk for developing moderate to severe AKI within 12 h with the high sensitivity of 92% [95% confidence interval (CI), 85–98%] (Bihorac et al., 2014).