These results were in agreement with previous studies of natural products, such as Poria cocos and Polyporus umbellatus as well as their components including poricoic acid A, poricoic acid ZM, poricoic acid ZP, and ergone against renal fibrosis by targeting IƙB/NF-ƙB and Keap1/Nrf2 signaling pathways (Feng et al., 2019b; Chen et al., 2019d; Chen et al., 2019e; Chen et al., 2019f; Wang et al., 2020b). Here, KEAP1 is linked to renal fibrosis.