In this research, a CRF rat model was induced by adenine orally, which was then administered with SKI and its bioactive components including chrysophanol, emodin, and rhein orally to determine whether they could improve CKD and slow down renal fibrosis by regulating the inhibitor of kappa B (IƙB)/NF-ƙB and Keap1/Nrf2 signaling pathways. This evidence concerns the gene ATP8A2 and renal fibrosis.