Of note, IƙB/NF-ƙB and Keap1/Nrf2 signaling pathways were the most important mediators in oxidative stress and inflammation that played a central role in the development and progression of CKD and its complications (Meng et al., 2014; Chen et al., 2016; Feng et al., 2019a). The gene discussed is ATP8A2; the disease is chronic kidney disease.