Myeloid Differentiation Primary Response 88 (Myd88) is a significant constituent of the signalling cascade downstream of IL-1β-IL-1R interaction, which ultimately converges with the canonical NF-κB signalling pathway leading to the further amplification of the inflammatory mediator production in RA (Avbelj et al., 2011; Chen et al., 2020). This evidence concerns the gene NFKB1 and rheumatoid arthritis.