We showed that RXA reversed the expression of filaggrin and VCAM-1 in both of Dfb-induced AD animal skin and TNF-α/IFN-γ-stimulated HaCaT keratinocytes, suggesting that the suppression of IL-6 level by RXA is implicated in its alleviatory effect against AD. The gene discussed is VCAM1; the disease is Alzheimer disease.