In line with the previous studies on the therapeutic effect of AhR activation (van den Bogaard et al., 2013), we observed reinforcing effects of RXA on SIRT1, AhR, and filaggrin in both of Dfb-induced AD animal skin, TNF-α/IFN-γ-stimulated HaCaT keratinocytes, and AD-like HSE model. This evidence concerns the gene SIRT1 and Alzheimer disease.