FLG and inflammatory skin disease: Moreover, it has been demonstrated that SIRT1, a member of the silent information regulator 2 family which catalyzes NAD+-dependent protein deacetylation (Bauer-Mehren et al., 2010), regulates filaggrin expression through AhR, thus indicating new roles of these markers in skin barrier function and shedding light on the molecular mechanisms that help maintaining the skin barrier and preventing inflammatory skin disease.