Additionally, the excessive ROS production may also increase the mitochondrial permeability transition (MPT) pore opening and promote the release of cytochrome C and other proapoptotic factors into the cytosol, causing the hepatocyte death and NASH progression (Haouzi et al., 2000; Ricchelli et al., 2011). Here, CYCS is linked to metabolic dysfunction-associated steatohepatitis.