CD274 and neoplasm: It has been shown that blocking of PD-1 on CTLs in a mouse model has the capacity to stimulate the PD-L1-NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway which in turn induces the placement of myeloid-derived suppressor cells (MDSCs) and promotes infiltration in the tumor cells (Mahoney et al., 2015).