The mechanism of QWZK protection against ALI induced by LPS may via inhibiting TLR4/NF-kB pathway and NLRP3 inflammasome activation and then downregulated the expression of IL-6, TNF-α, MCP-1, IL-1β, IL-18, and IFN-γ (Figure 7). This evidence concerns the gene IL18 and acute respiratory distress syndrome.