Coumarin compound, emodin, alleviated LPS-induced pulmonary inflammation in rat lung tissues through inhibiting the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor 1-alpha (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway (Li et al., 2020). The gene discussed is VEGFA; the disease is inflammatory response.