ALI/ARDS induced by COVID-19 overproduces early response proinflammatory cytokines TNF-α, interleukin (IL)-6, and IL-1β, which results in cytokine storm, and then leads to vascular hyperpermeability, multiorgan failure, high cytokine concentrations unabated over time, and eventually death (England et al., 2021). The gene discussed is IL1B; the disease is acute respiratory distress syndrome.