The activation of the NF-κB signaling pathway resulted in the apoptotic resistance of lung fibroblasts (Golan-Gerstl et al., 2012), but blocking NF-κB signaling attenuated bleomycin (BLM)-induced lung fibrosis via suppressing myofibroblast differentiation (Hou et al., 2018). This evidence concerns the gene NFKB1 and pulmonary fibrosis.