Contrary to our and others’ results, Kan et al. (Kan et al., 2015) reported that LTBP2 negatively regulated NF-κB p65 by decreasing phosphorylation of p65 at serine 536, inhibiting active phosphorylated p65 nuclear localization and weakening the p65 DNA-binding ability in nasopharyngeal carcinoma. This evidence concerns the gene RELA and nasopharyngeal carcinoma.