Disturbed flow similarly induces NF-κB and hypoxia inducible factor 1α expression, EC proliferation, and inflammation via upregulation of glycolytic enzymes (Feng et al., 2017), and can also promote EC activation and atherosclerosis through YAP/tafazzin (TAZ) signaling (Wang K.-C. The gene discussed is TAFAZZIN; the disease is atherosclerosis.