Fifty-nine patients had functional data during the 24-month follow-up including 34 CTD-ILD (23.5% males; mean age 58.42 ± 13.01 years) and 25 IPAF (48.0% males; mean age 69.02 ± 12.51 years) patients. The gene discussed is NLRC4; the disease is interstitial lung disease.