CD276 has been reported to promote tumor progression by inhibiting the functions of NK and CD8+ T cells, and its expression levels were associated with poor prognosis in multiple cancers (Zang et al., 2007; Crispen et al., 2008; Zhang et al., 2009; Lee et al., 2017; Inamura et al., 2018). The gene discussed is CD8A; the disease is neoplasm.