KCNB1 and pulmonary arterial hypertension: A reduction in Kv channels, in particular Kv1.2, Kv1.5, and Kv2.1, have been proven in the pathogenesis of hypoxia-induced pulmonary hypertension, leading to pulmonary vasoconstriction and vascular remodeling, while the upregulation of Kv channels is of therapeutic significance for pulmonary hypertension (Jackson et al., 2018).