NFE2L2 and rheumatoid arthritis: Quercetin, another anti-RA monomer, has been shown to act on anti-inflammatory, analgesic and anti-oxidant effects via the suppression of NF-κB and the activation of nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase (HO-1) pathway (Guazelli et al., 2018; Yang et al., 2018).