The n-butanol extraction of Panax notoginseng (Chang et al., 2007), and sodium tanshinone IIA (TIIA) sulfonate (Wang et al., 2019c) can play the role of anti-TNF-α and various inflammatory cytokines by inhibiting NF-κB and MAPK signaling pathways, improving the symptoms of the experimental RA models in vitro and vivo. Paeonia lactiflora Pallas and total glucosides of paeony (TGP) exert anti-inflammatory, analgesic, inhibiting synovial hyperplasia and angiogenesis, and therefore can be clinically applied in the treatment of RA (Zhang and Dai, 2012). Here, TNF is linked to rheumatoid arthritis.