In addition to skilled rheumatologists making decisions about RA based on typical clinical signs and symptoms, it is also necessary to selectively detect various serological indicators related to RA, such as RF, C-reactive protein, erythrocyte sedimentation rate, glucose-6-phosphate isomerase, IL-6, IL-1, anti-keratin, anti-perinuclear factor, anti-cyclic citrullinated peptide, anti-RA33, anti-Sa, and anti-p68 antibodies (Kumar et al., 2016; Malmström et al., 2017). This evidence concerns the gene IL1B and rheumatoid arthritis.