Many evidence has confirmed that curcumin could inhibit RA-evoked inflammatory process, oxidative stress events (Manca et al., 2019), and synovial hyperplasia (Dai et al., 2018), by the inhibition of NF-κB signal transduction and induction of macrophage apoptosis (Wang et al., 2019a), as well targeting mTOR pathway (Dai et al., 2018). Here, NFKB1 is linked to rheumatoid arthritis.