TNF and rheumatoid arthritis: In vivo and in vitro evidence also suggests that quercetin could maintain the Th17/Treg ratio, repress the activation of NLRP3 inflammasome (Yang et al., 2018), and downregulate the levels of inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-17, MMP and monocyte chemoattractant protein (MCP-1) in experimental RA models (Haleagrahara et al., 2018).