PPARG and hyperhomocysteinemia: Moreover, berberine reversed homocysteine thiolactone induced ROS and promoted atherosclerotic plaque stability in Apoe−/- mice with hyperhomocysteinemia through the mechanism of activating peroxisome proliferator-activated receptor gamma (PPARγ), a transcriptional factor against oxidative stress and inflammation (Li et al., 2016; Idris-Khodja et al., 2017).