Moreover, GLP-1 RA therapy plus standard hypoglycemic drugs, compared to standard hypoglycemic drugs alone, for the treatment of diabetic patients that are undergoing cardiac resynchronization therapy with a defibrillator (CRT-d) for a failing heart has lead to significant improvements in left ventricular ejection fraction, a reduction in New York Heart Association class, arrhythmic burden, and hospitalization for heart failure worsening, and a 3.7-fold higher rate of CRTd responders (Sardu et al., 2018). Here, GLP1R is linked to heart failure.