Therefore, the objective of the present study was to conduct a network meta-analysis with a systematic review of all COVTs of GLP-1 RAs in order to: (1) compare the primary outcomes reported, including cardiovascular outcomes, hypoglycemia, pancreatitis, thyroid medullary, and papillary carcinoma, (2) compare the secondary outcomes reported in a subset of the CVOTs, including composite kidney outcome, worsening kidney function, macroalbuminuria, retinopathy, and (3) rank the integrative effect of GFP-1 RAs on both primary and secondary outcomes in T2DM patients. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.