For example, it is know that CDK4 activation in CDK4R24C/R24CApc+/min mice leads to significant increased in tumor vascularity in comparison to CDK4+/+Apc+/min mice or APC+/min mice (Abedin et al., 2010), while knocking out CDK4 in APC+/min mice reduces adenoma development (Karim et al., 2013). Here, APC is linked to adenoma.