EGFR and neoplasm: For example, the aptamers human epidermal growth factor receptor-2 (Zhang et al., 2017), epidermal growth factor receptor (EGFR) (Figure 6B) (Zhang et al., 2021), and folate (Lee et al., 2017) have been conjugated to 3WJ-pRNA for the targeted delivery of RNAs to tumor tissues, and the specifically delivered RNAs significantly regressed tumor growth and improved survival.