In the lung, CCL2 is mainly produced by lung macrophages, T cells and endothelial cells and is involved in endothelial and pulmonary epithelial cell proliferation, migration and wound closure, and is associated with a variety of diseases with disorders of lung inflammation, including COPD (Henrot et al., 2019), acute respiratory distress syndrome, allergic asthma and idiopathic pulmonary fibrosis (Rose et al., 2003). Here, CCL2 is linked to inflammatory response.