Meanwhile, alpha-synuclein pathology plays a very important role in PD progression (Rai et al., 2017; Zahra et al., 2020), and increasing evidence suggests that alpha-synuclein invasion could activate M1 microglia, which then promote the transmission of alpha-synuclein to neuronal cells via exosomal pathways (Xia et al., 2019). The gene discussed is SNCA; the disease is Parkinson disease.