In premenopausal subjects (Supplementary Table 3), multivariate Cox proportional hazards regression analysis demonstrated that baseline E2 and FSH levels were significantly associated with the risk of POAG progression (HR = 0.04, 95% CI = 0.01 – 0.34, p < 0.01, and HR = 5.36, 95% CI = 1.39–20.74, p = 0.02, respectively). Here, BRD2 is linked to open-angle glaucoma.