To test this hypothesis by determining the effects of sex hormones on the onset of POAG, we performed a cross-sectional study in women with POAG that assessed the levels of six sex hormones: prolactin (PRL), luteinizing hormone (LH), testosterone (TESTO), follicle-stimulating hormone (FSH), PROG, and E2. This evidence concerns the gene PLOD1 and open-angle glaucoma.