MAPT and Alzheimer disease: In amyloid (APPswe/PS-1L166P) and tau (Thy-TAU22) transgenic mouse models, single microglia sequencing confirmed that Aβ, not Tau pathology induces marked transcriptional changes in microglia, including increased proportions of ARM with genetic signature enriched for AD risk genes (Sierksma et al., 2020; Table 1).