Using massively parallel scRNA-seq (MARS-seq), Keren-Shaul et al. (2017) mapped the immune cells (CD45+) in mouse brains and identified microglia clusters with distinct gene expression profiles, that were referred to as neurodegenerative disease-associated microglia (DAM), in the cortical regions of 5XFAD (AD transgenic mouse model that expresses five human familial AD gene mutations) mouse brains where Aβ plaques are massively deposited. Here, PTPRC is linked to Alzheimer disease.