Going beyond the ApoE gene, Jahanshad et al. (2013) used a dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to carry out a GWAS of brain connectivity measures and found an associated variant in F-spondin (SPON1), previously known for its association with dementia severity. Here, SPON1 is linked to early-onset autosomal dominant Alzheimer disease.