CREB is also a central target for diverse classes of antidepressant treatments, contributes to the neurotrophic, neurogenic and behavioral effects of antidepressants (Nibuya et al., 1996; Duman and Nibuya, 1997; Thome et al., 2000; Chen et al., 2001; Nair and Vaidya, 2006), and is dysregulated in both animal models of depression (Carlezon et al., 2005; Duman et al., 2005; Krishnan and Nestler, 2008, 2010) and in major depressive disorder patients (Blendy et al., 1996; Koch et al., 2009). Here, CREB1 is linked to major depressive disorder.