In the included studies, Mdivi-1 treatment reduced the level of dysfunctional mitochondrial detectors (i.e., PINK1 and Parkin) and maintained the number of healthy mitochondria, suggesting that Mdivi-1 might attenuate the impairment of neural mitochondrial functions to reduce the neural mitophagy in I/R-induced brain injury (Zhang et al., 2014; Huang et al., 2021). This evidence concerns the gene PRKN and brain injury.