Likewise, previous studies showed that the intravenous injection of Mdivi-1 (1.2 mg/kg) could reduce the TUNEL-apoptotic positive cells as well as the protein levels of Bax, cytochrome c, and cleaved caspase-3 in the brains of Sprague Dawley rats after subarachnoid hemorrhage (Fan et al., 2017; Wu et al., 2017). This evidence concerns the gene CASP3 and subarachnoid hemorrhage.