MFN1 and brain injury: Regarding the effects of Mdivi-1 on neural mitochondrial fusion, the included studies showed that Mdivi-1 only increased neural outer membrane mitochondrial fusion (e.g., Mfn1 factor) but did not affect the neural inner membrane mitochondrial fusion (e.g., Opa1 factor) in I/R-induced brain injury (Ma et al., 2016; Huang et al., 2021).