There are many genes linked to ALS-TDP including Optineurin, TBK1, TARDBP, C9ORF72, and CHMP2B among others (Nguyen et al., 2018; Shatunov and Al-Chalabi, 2021), and this genetic heterogeneity suggests several possible triggering events leading to a final common pathway of TDP-43 pathology. This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.