Other RBPs that are sequestered in C9ORF72-ALS/FTD include ALYREF, SRSF2 and hnRNP-A1 and F (Cooper-Knock et al., 2014), and proteins with RRM or functions linked to splicing and mRNA transport are considered to be vulnerable. This evidence concerns the gene HNRNPA1 and frontotemporal dementia.