This process most probably occurs because of a higher protein density in the granules, with a consequent liquid-to-solid phase change of SGs, exceedingly facilitated by ALS-related proteins with a prion-like low-complexity domain, like TDP-43, Ataxin-1, Ataxin-2 and FUS (Li et al., 2013; Pakravan et al., 2021). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.