TARDBP and amyotrophic lateral sclerosis: Mutations in genes coding for RNA/DNA-binding proteins (RBPs), such as TARDBP, located on chromosome 1 p36.22, and FUS, located on chromosome 16 p11.2, are associated with ALS and are implicated in the pathogenesis of the disease (Neumann et al., 2006; Van Deerlin et al., 2008; Kwiatkowski et al., 2009; Vance et al., 2009; Ederle and Dormann, 2017).