FUS and amyotrophic lateral sclerosis: Mutations of the FUS protein at the NLS domain cause a form of ALS with an aggressive phenotype (Chiò et al., 2009; Conte et al., 2012; Kuang et al., 2017), being also responsible for the massive nucleus-to-cytoplasm misplacement of the protein (Kwiatkowski et al., 2009; Vance et al., 2009, 2013; Dormann et al., 2010; Lo Bello et al., 2017).