The status of TP53 mutation matched well with the p53 IHC results in EC, SC, CS, and LCNEC cases (33/36), except for two EC cases (no. 6 and 11) and one DC case (no.21) that exhibited wt p53 IHC but harbored TP53 mutations. The gene discussed is TP53; the disease is large cell neuroendocrine carcinoma.