In consistent with the findings in vitro, we observed a lower expression of miR-138-5p and a higher level of EZH2 in macrophages isolated from the vector ARDS mice in comparison with the sham group; circN4bp1-KD treatment can restore the expression of miR-138-5p but decrease the levels of EZH2 (Figures 7(g) and 7(h)). Here, EZH2 is linked to acute respiratory distress syndrome.