Based on previous data from our laboratory [11], circN4bp1 (chr8: 86865721-86866760) was of particular interest because one of its most likely targeted gene, EZH2 (a histone methyltransferase), had been previously documented by our team to be involved in sepsis-induced inflammation and lung injury through modulating macrophage M1 polarization [13]. Here, EZH2 is linked to Sepsis.