Furthermore, plasma Ang II level was lower (Fig. 7A), myocardial infarct size (Fig. 7F-G) was smaller and plasma CK-MB level and cTn-I level (Fig. 7H-I) were lower, LVEF and LVFS were higher, and LVESd and LVEDd were shorter (Fig. 7J-N), the SOD activity of myocardial tissue was higher, and the MDA activity of myocardial tissue was lower in I/R + C3 group than that in I/R + C3 + GPR41-shRNA group (Fig. 7O-P). Here, TNNI3 is linked to myocardial infarction.