LINE-1 ORF-1p (LINE-1 ORF-1p is encoded by the human pro-oncogene LINE-1) interacts with PXR and enhances its cytoplasmic/nuclear translocation, and further mediates the resistance to and clearance of sorafenib in HCC cells by inducing CYP3A4 and MDR1 118 . The gene discussed is CYP3A4; the disease is hepatocellular carcinoma.