NR1I2 and lung carcinoma: Currently, PXR SNPs (rs3732359, rs3732360 and rs3814058) have been linked to the decreased percentage in nadir haemoglobin, suggesting increased docetaxel-associated toxicity in nasopharyngeal carcinoma patients and PXR (rs3814058C>T) polymorphism increases the risk of lung cancer in smokers 23, 24.