MAPK3 and non-small cell lung carcinoma: SFN metabolites phosphorylate ERK1/2, leading to upregulation of 26S proteasome and Hsp70, as well as downregulation of βIII-tubulin, X-linked inhibitor of apoptosis protein (XIAP), Tau, Stathmin1, and α-tubulin, ultimately develops microtubule catastrophe, then reverses PTX resistance in NSCLC cells 152.