Rhamnetin as an inhibitor of SIRT1, enhances miR-148a transcription thus inhibits PXR/CYP3A4/MDR1 signal, slowing down the metabolic detoxification of sorafenib in HCC cells and enhancing the sensitivity of HCC cells to sorafenib 127. Here, CYP3A4 is linked to hepatocellular carcinoma.