Consistent with our previous findings about DAPK1 and Pin1 14, we found that the activation of DAPK1 by Aβ42 species also led to Pin1 inactivation through Ser71 phosphorylation, which agrees with Sultana et al.'s finding that AD patients have a significant loss of Pin1 activity in the hippocampus compared with healthy controls 45. Here, PIN1 is linked to Alzheimer disease.