Overexpression of the receptor due to its association with: increased c-Myc, human epidermal growth factor receptor 2 (HER-2)/neu, and EGFR, as well as a reduction in prohibitin and RIIb, facilitates the increase in cell proliferation and induces a concomitant aggressiveness of the carcinoma 94. The gene discussed is ERBB2; the disease is carcinoma.