KDR and retinal disorder: Specifically, the researchers applied recombinant AAV serotype 1 (rAAV1)-mediated CRISPR/Cas9 to successfully edit the vascular endothelial growth factor receptor 2 (Vegfr2) genomic loci of ECs and disrupt angiogenesis in mouse models of laser induced choroid neovascularization and oxygen-induced retinopathy 17.