As shown in the heatmaps (Figures 1C-E), the hsa_circ_0001495, miR-125b-5p, and GPM6A were down-regulated in cancer tissues compared to their paired para-carcinomal tissues of HCC, whereas hsa_circ_0000688, miR-106b-5p, and four mRNAs (UNKL, GPRIN1, SMYD5, AURKB) were up-regulated. This evidence concerns the gene SMYD5 and cancer.