CTNNB1 and hepatocellular carcinoma: Another study found that an HCC subtype overexpressing AFP (median serum level, 472 ng/mL) exhibited tyrosine kinase activation (IGF1R, RPS6 and Akt phosphorylation), decreased frequencies of CTNNB1 exon 3 mutation and 6q loss, increased frequencies of 4q and 13q loss and significant macrovascular invasion90.