As a hallmark in DNA repair, genomic stability and apoptosis regulation, TP53 mutation was found to be correlated with AFP positivity, as there were 50.00% (12/24) of AFP-positive HCC in the TP53 mutation group and 20.69% (6/29) in the wild type (p < 0.05)91. The gene discussed is AFP; the disease is hepatocellular carcinoma.