TP53 and hepatocellular carcinoma: In addition, TP53 mutation was proven to be associated with a novel histological subtype called "macrotrabecular-massive HCC (MTM-HCC)", which was designated by Calderaro et al. and characterized by a predominant macrotrabecular architecture involving more than 50% of the tumor, high AFP serum levels (AFP > 100 ng/ml, P < 0.02) and poor recurrence-free survival15, 94.