AFP and hepatocellular carcinoma: Yamashita et al. classified HCC into four subtypes by EpCAM and AFP (EpCAM- AFP-, EpCAM- AFP+, EpCAM+ AFP- and EpCAM+ AFP+ HCC) with the name of mature hepatocyte-like HCC, hepatocytic progenitor-like HCC, bile duct epithelium-like HCC and hepatic stem cell-like HCC83, 84.