LHPP and neoplasm: IHC staining also illustrate that LHPP expression was significant in normal oral mucosas with an MOD of 0.033, decreased expression of LHPP in highly differentiated OSCC tissues with an MOD of 0.024, but almost no expression was found in moderately and poorly differentiated OSCC tissues with an MOD of 0.006 and 0.0018, indicating that LHPP can be used as a key factor to determine the degree of tumor differentiation (Figure 2A, B).The negative and positive controls used in immunohistochemistry were obtained from The Human Protein Atlas (http://www.proteinatlas.org/) 17.