Thus, cathepsin K serves its valuable action for the evaluation of joint destruction in patients suffering from rheumatoid arthritis and the potential candidate which can inhibit cathepsin can serve as potential therapy, thereby preventing joint destruction (Wilson et al., 2009, Li et al., 2002, Troen, 2006, Kiviranta et al., 2005). This evidence concerns the gene CTSS and rheumatoid arthritis.