METTL3 plays a similar role in cerebral arteriovenous malformation, and deletion of METTL3 in ECs significantly affects angiogenesis by reducing heterodimeric Notch E3 ubiquitin ligase formed by DTX1 and DTX3L (Wang et al., 2020). The gene discussed is DTX3L; the disease is arteriovenous malformations of the brain.