As we assayed all CDKN2A VUSs reported in these studies, our data indicate that the prevalence of likely pathogenic germline CDKN2A variants initially characterized as VUSs is 1.6% (95% CI: 0.8–2.9%) in patients with familial pancreatic cancer, 0.9% (95% CI: 0.5–1.8%) in patients with PDAC positive family history of PDAC (including patients that did not meet the criteria for classification as familial pancreatic cancer), and 0.1% (95% CI: 0.02–0.3%) in PDAC patients unselected for family history. This evidence concerns the gene CDKN2A and familial pancreatic carcinoma.