By detecting the level of serum anti-dsDNA antibody and urinary protein in mice, we further clarified that interfering with the expression of CD40L and BDH2 in systemic lupus erythematosus mice simultaneously recovered the level of serum anti-dsDNA antibody (Figure 4(f)) and urinary protein in mice (Figure 4(g)) comparing with mice only interfering with CD40L. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.