As the dehydrogenase, which mediated 2, 5-dihydroxybenzoic acid’s formation, BDH2 exerted a critical influence on iron assimilation and homeostasis as well as the susceptibility to infectious diseases based on an assimilable source of iron exploited by pathogenic bacteria; besides, it also plays a role in a 3-hydroxybutyrate dehydrogenase [36]. Here, BDH1 is linked to infectious disease.