Alterations in other proteins involved in triad formation and maintenance, including caveolin-3 (CAV3), amphiphysin-1 (BIN1), dysferlin (DYSF), myotubularin (MTM1), and striated muscle preferentially expressed protein kinase (SPEG), have also been linked to skeletal myopathy phenotypes in patients and rodent models (118, 132, 229). The gene discussed is SPEG; the disease is skeletal muscle disorder.