Current studies have shown that FGF members, such as FGF‐2, FGF‐9, FGF‐18 and FGF‐19, have been closely implicated into the physiology and pathology of cartilage and they can promote the development of cartilage and bone,1, 9, 12, 13, 14, 15, 16 but the specific role of FGF‐8 subfamily in the growth and development of cartilage and cartilage disease progression remains partially known. Here, FGF8 is linked to cartilage disease.