An X‐linked female limited inheritance pattern is quite exceptional and only known from craniofrontonasal syndrome caused by EFNB1 mutations (Twigg et al., 2004; Wieland et al., 2004) (MIM# 304110) and epilepsy in females caused by PCDH19 mutations variants (Jamal et al., 2010) (MIM# 300088). Here, EFNB1 is linked to Craniofrontonasal dysplasia.