First, it gives insights into the prognosis since this ARR3 mutation causes high degrees of myopia, increasing the risks of visual blinding complications such as glaucoma, cataracts, retinal detachment, and myopic macular degeneration which led to the loss of independence and inability to work in adult life in some of our patients (Haarman et al., 2020). This evidence concerns the gene ARR3 and myopia.