DA should be discontinued in pregnancy (see below at 5.e.iii) and might be withheld in some particular cases, such as perimenopausal women, asymptomatic postmenopausal women, or asymptomatic men without hypogonadism in whom simple observation with periodic monitoring of PRL could be considered (114, 115, 116, 117). The gene discussed is PRL; the disease is hypogonadism.