PRL and neoplasm: Different studies reported that different factors are able to affect positively the success rate of DA withdrawal, such as the rate of PRL decrease after the start of DA treatment (120), tapering Cab dose before withdrawal (144), low-dose (0.5 mg/week) maintenance therapy for at least 1 year, restoration of a normal serum PRL level, and a significant reduction in tumor size or its disappearance (142, 143, 144).