A recent multicenter study collected the long-term results in 289 patients and showed tumor growth control in 95% of treated adenomas (5% had tumor progression) at last follow-up (mean 60 months up to 267 months) and normalization of PRL levels in 43% of the patients at 5 years and 54% at 8 years (182). The gene discussed is PRL; the disease is neoplasm.