It has been reported that the first PRL values obtained during treatment (either evaluated as absolute value or as percent decrease from baseline or as lowering below a predefined threshold, according to different series) as well as early tumor shrinkage (with different cut-offs in different series) are good predictors of long-term DA efficacy (120), either evaluated at 6 months (121) or even earlier (122, 123, 124). Here, PRL is linked to neoplasm.